Kennedy’s disease presented with mastication fatigue combined with positive titin antibody: a case report
Spinal and bulbar muscular atrophy (SBMA) is an X-linked recessive hereditary neuromuscular disorder caused by the expanded trinucleotide repeat in the androgen receptors gene. The major clinical manifestations of SBMA consist of weakness in the bulbar and limb muscles, fasciculations, tremors, cramps, sensory impairment, and gynecomastia. However, atypical SBMA cases may lead to misdiagnosis. Muscular fatigue and decremental responses to repetitive nerve stimulation (RNS), despite being observed in some SBMA patients, are usually occurred in MG patients, and patient with the symptom of mastication fatigue was rarely reported. To read the research study, click here.
Groundbreaking’ Cybernetic Therapy Improves Walking in SBMA
Two years of training with a wearable cyborg hybrid assistive limb (HAL), combined with leuprorelin therapy, markedly improved the walking abilities of a man with spinal and bulbar muscular atrophy (SBMA), a case study reports. This report describes the first successful case in the history of SBMA treatment in which the improvement and maintenance of ambulatory [walking] motor function were observed over [two] years, To read the report, click here.
Testing Synthetic Curcumin Analogs as Potential Treatments for Kennedy's Disease
Spinal and bulbar muscular atrophy (SBMA), also known as Kennedy’s disease, is a genetic neuromuscular disorder caused by expansion of a polyglutamine tract in the androgen receptor (AR). Acurcumin-related compound has been found to counteract the toxicity of mutant AR in the SBMA mouse model by reducing AR protein levels. Using cellular and transgenic mouse models of SBMA, we aimed to test the effects and investigate the mechanisms of action of two orally activecurcuminanalogs, ASC-J9 and ASC-JM17. To read the article, click here.
Application Value of the Motor Unit Number Index in Patients With Kennedy Disease
The aim of this study was to evaluate the usefulness of the motor unit number index (MUNIX) technique in Kennedy disease (KD) and test the correlation between the MUNIX and other clinical parameters. The MUNIX values of the bilateral deltoid, abductor digiti minimi (ADM), quadriceps femoris (QF), and tibialis anterior (TA) were determined and compared with the course of the disease.. To read the article, click here.